FIGURE 2.

Levels of regulation of YAP and TAZ YAP/TAZ regulation is fine-tuned and mediated by external stimuli or soluble factors via LATS1/2 (in green: 1, 2, and 3) that phosphorylates YAP/TAZ (in yellow: 4). YAP/TAZ localization and degradation could be also modulated at different levels (in blue: 5, 6, 7, and 8). Phosphorylated inactive YAP/TAZ can induce cytoplasmic sequestration of β-catenin and inhibit Wnt/β-catenin signaling by inhibiting Dvl translocation to LRP5/6-Frizzled complex. Phosphorylated YAP/TAZ are also present in the β-catenin proteosomal degradation complex. YAP/TAZ could also be a transcriptional co-factor for β-catenin and its interaction with TCF/LEF. Finally, non-canonical Wnt/β-catenin signaling inhibits YAP/TAZ phosphorylation via LATS1/2.