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. 2022 Jan 4;9:788773. doi: 10.3389/fcell.2021.788773

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Copyright © 2022 Zarka, Haÿ and Cohen-Solal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Levels of regulation of YAP and TAZ YAP/TAZ regulation is fine-tuned and mediated by external stimuli or soluble factors via LATS1/2 (in green: 1, 2, and 3) that phosphorylates YAP/TAZ (in yellow: 4). YAP/TAZ localization and degradation could be also modulated at different levels (in blue: 5, 6, 7, and 8). Phosphorylated inactive YAP/TAZ can induce cytoplasmic sequestration of β-catenin and inhibit Wnt/β-catenin signaling by inhibiting Dvl translocation to LRP5/6-Frizzled complex. Phosphorylated YAP/TAZ are also present in the β-catenin proteosomal degradation complex. YAP/TAZ could also be a transcriptional co-factor for β-catenin and its interaction with TCF/LEF. Finally, non-canonical Wnt/β-catenin signaling inhibits YAP/TAZ phosphorylation via LATS1/2.