Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 4;9:788773. doi: 10.3389/fcell.2021.788773

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Zarka, Haÿ and Cohen-Solal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

YAP/TAZ in bone and cartilage biology YAP/TAZ regulates mesenchymal stem cell commitment toward an osteoblastic lineage and inhibits adipogenesis and chondrogenesis by inhibiting PPARγ, and BMP, respectively. This process allows for osteoblast differentiation in relation to microenvironment modifications such as shear stress, absence of cellular contact, and/or a stiff matrix that promotes YAP/TAZ activation. YAP/TAZ regulate osteoblastogenesis by modulating Runx2 and the Wnt/β-catenin pathway.