TABLE 1.

Partners of YAP/TAZ in bone and cartilage.

Bone partners	Cellular consequences	References
α-catenin	Cytoplamic retention of YAP to establish a group of non-dividing and specialized cells for formation of the tooth signalling centre, the enamel knot (EK)	Li et al. (2016)
Snail/Slug	Interaction inside the complex Snail/Slug-YAP/TAZ-Runx2 to stimulate MSC differentiation	Tang et al. (2016)
Runx2	Stimulate Osteocalcin gene expression and osteoblastogenesis	Cui et al. (2003), Hong et al. (2005)
PPARγ	Inhibit adipogenesis	Hong et al. (2005)
β-catenin	Stimulate osteoblastogenesis	Pan et al. (2018)
Smad1/5/8	Stimulate osteoblastogenesis in response to BMP-2	Wei et al. (2020)

YAP/TAZ, interacts in protein complex with different signaling pathway such as TGFβ/BMPs, and the Wnt/β-catenin pathway. YAP/TAZ, also interacts as DNA, and binding partners with Runx2.