TABLE 2.
Bone phenotype induced by YAP and TAZ modulation.
| Genotype | Stage of differentiation | Bone structure | Histo-morphometric parameters | Age | References |
|---|---|---|---|---|---|
| YAPfl/fl; TAZfl/fl; Prx1Cre | Mesenchymal stem cells | Lethality (severe hemorrhage and edema) | — | Embryonic lethality | Xiong et al. (2018) |
| YAPfl/fl; TAZfl/fl; OsxCre | Young osteoblasts | Lethality (neonatal asphyxiation due to ribcage malformation, fracture) | — | Neonatal lethality | Kegelman et al. (2018) |
| YAPfl/+; TAZfl/fl; Prx1Cre | Mesenchymal stem cells | BV/TV + Ct. Th + | Ob. N/BS + Oc. N/BS = MS/BS + MAR = BFR/BS + | 12-week-old-female | Xiong et al. (2018) |
| YAPfl/+; TAZfl/+; OsxCreYAPfl/fl; TAZfl/+; OsxCre TAZfl/fl; YAPfl/+; OsxCre | Young osteoblasts | BV/TV− Ct. Th − | Ob. N/BS − Oc. N/BS + MS/BS = MAR − BFR/BS = | 8-week-old male | Kegelman et al. (2018) |
| YAPfl/fl; OcnCre | Osteoblasts | BV/TV − Ct. Th = | Ob. N/BS − MAR − BFR/BS − | 3-month-old male | Pan et al. (2018) |
| YAPfl/fl; TAZfl/fl; DMP1Cre | Mature osteoblasts/osteocytes | BV/TV − Ct. Th − | Ob. N/BS − Oc. N/BS + MS/BS − MAR − BFR/BS − | 12-week-old-male | Xiong et al. (2018) |
| YAPfl/fl; TAZfl/fl; DMP1(8 kb)Cre | Mature osteoblasts/osteocytes | BV/TV − Ct. Th − | Ob. N/BS − Oc. N/BS + MS/BS − MAR − BFR/BS − | Post-natal-day 84 | Kegelman et al. (2020) |
Synthesis of the bone phenotype observed in different mouse models invalidated for YAP, and/or TAZ, at different stages of differentiation. YAP/TAZ, deletion in osteoprogenitors results in lethality, and later invalidation using Osx, and Ocn or DMP1-Cre decreases bone volume. Obl.S/BS, osteoblast surface, Oc.S/BS, osteoclast surface, MS/BS, mineralized surface/bone surface, MAR, mineral apposition rate, and BFR/BS, bone formation rate/bone surface.