TABLE 3.

Cartilage phenotype induced by YAP and TAZ modulation.

Genotype or model	YAP/TAZ status	Effect on cartilage and OA	References
Mob1afl/fl; Mob1b−/−; Col2a1CreERT	YAP/TAZ overexpression from P0	Chondrodysplasia phenotype	Goto et al. (2018)
nls-YAP5SAKI/+; Col2a1Cre	YAP overexpression	Chondrodysplasia phenotype	Vanyai et al. (2020)
Tg-Col2a1-YAP	YAP overexpression	Protects from OA	Deng et al. (2018a)
Mst1fl/fl; Mst2fl/flCol2a1Cre	YAP/TAZ overexpression	Protects from OA	Deng et al. (2018b)
Intra-articular injection of YAP siRNA	YAP silencing	Protects from OA	Gong et al. (2019)
Intra-articular injection of YAP inhibitor, Verteporfin	YAP/TAZ silencing	Protects from OA	Zhang et al. (2020)
YAPfl/fl; Col2a1CreERT	YAP silencing from 8 week-old	Protects from OA	Zhang et al. (2020)
Yapfl/fl; Tazfl/fl; Col2a1Cre	YAP/TAZ silencing	Neonatal lethality	Vanyai et al. (2020)

Synthesis of cartilage phenotypes induced by YAP, or YAP/TAZ, silencing, and upregulation in vivo found in the literature. OA, osteoarthritis.