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. 2022 Jan 4;11:775663. doi: 10.3389/fcimb.2021.775663

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Copyright © 2022 Zhao, Li, Zhou, Pan, Zhao, Yang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NK depletion altered cytokine production of macrophages. Lung macrophages were isolated from C.muridarum-infected NK-intact (NK+Mφs) and NK-depleted mice (NK-Mφs) at day 7 p.i. (A) The mRNA expression of TNF-α, IL-6 and IL-10 by NK+Mφs and NK-Mφs. (B) The protein levels of cytokines in the supernatants of sorted NK+Mφs and NK-Mφs were assayed by ELISA. Data are shown as mean ± S.D (n=5) and are representative of three independent experiments with similar results. **p < 0.01; ***p < 0.001.