FIGURE 1.

Neuroinflammatory response at early stage ME7 prion disease. Neuroinflammatory response in the hippocampus and thalamus of ME7 prion mice 4 weeks after systemic injection of saline or 1 × 10⁶ cfu S. typhimurium SL3261 at 8-wpi. Representative images showing CD11b (A,C) and MHCII (B,D) expression. Scale bar = 200 microns. Quantification of staining shows increased expression after systemic infection with S. typhimurium compared to saline injection for CD11b (E) and MHCII (F). *p < 0.05; ***p < 0.001 vs. ME7 + saline using one-tailed unpaired Students’ t-test on log-transformed values; n = 4–5/group.