FIGURE 2.

Neuroinflammatory response at mid-stage ME7 prion disease. Neuroinflammatory response in the hippocampus and thalamus of ME7 prion mice 4 weeks after systemic injection of saline or 1 × 10⁶ cfu S. typhimurium SL3261 at 12-wpi. Representative images showing CD11b (A,C) and MHCII (B,D) expression. Scale bar = 200 microns. Quantification of staining shows increased expression after systemic infection with S. typhimurium compared to saline injection for CD11b (E) but not MHCII (F). *p < 0.05 vs. ME7 + saline using one-tailed Mann-Whitney U-test; n = 3/group.