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Burrowing activity. The impact of systemic bacterial infection on burrowing behaviors in ME7 prion mice. ME7 prion mice were challenged with saline (closed squares) or 1 × 106 colony forming units S. typhimurium SL3261 (open squares) at 8 weeks after inoculation and followed for 4 weeks. NBH-injected mice were included as control. *p < 0.05 using one-way ANOVA with Holm-Sidak test for multiple comparisons; n = 4–5/group.
