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(A) Chromatograms showing the loss of heterozygosity of SDHA germline variants in tumor tissue of eight GIST patients. Black arrows indicate the position of the mutation; the asterisk indicates a silent single nucleotide polymorphism. (B) SDHA germline variant frequency of GIST patients coming from this series (written protein mutation) and from previous reports (3, 7, 8, 11–17), shown as lollipop plot.
