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. 2022 Jan 4;8:806988. doi: 10.3389/fcvm.2021.806988

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Copyright © 2022 Lin, Ding, Li, Feng, He, Huang and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epigenetic strategies to reduce vascular aging. Exercise, drug, circadian clock, and diet play important role in altering epigenetic modifications and in reducing vascular aging. ASC, factor–apoptosis-associated speck-like protein containing CARD, SMYD1, SET- and MYND- domain containing protein 1; SIRT, sirtuin; SCM-198, leonurine; β-HB, β-hydroxybutyrate. A detail of this figure is elaborated in section the epigenetic intervention strategies of vascular aging.