TABLE 1.
List of putative PPI-binding proteins and enzymes
| PlasmodDB accession number | Domain | TGDa | Growth disadvantage | Pf Piggyback MIS/MFS (Zhang et al, 2018) | PbKO (Bushell et al, 2017) | TgKO (Sidik et al, 2016) |
|---|---|---|---|---|---|---|
| PF3D7_1459600 | ENTH | NO | NA | 0,12/−3 | Yes | −4,16 |
| PF3D7_1310300 | FYVE | NO | NA | 0,12/−3,11 | No data | Plasmodium specific |
| PF3D7_1460100 | FYVE (FCP) | NO | NA | 0,12/−3,05 | No data | −1,4 |
| PF3D7_0307800 | PDZ | NO | NA | 0,15/−2,75 | No data | −3,27 |
| PF3D7_0414600 | PH (APH) | NO | NA | 0,68/−2,21 | Slow growth | −5,53 |
| PF3D7_1337700 | PH (PfPH2) | NO | NA | 0,13/−2,93 | No data | 0,26 |
| PF3D7_1146100 | PH | NO | NA | 0,14/−2,89 | No data | 1,91 |
| PF3D7_1131800 | PH (OSBP) | Yes | Not significant | 1/0 | Slow growth | −6,07 |
| PF3D7_1019600 | PH | NO | NA | 1/−0,2 | Yes | Not in Tg |
| PF3D7_1361500 | PH | Yes | Yes | 0,93/−1,93 | No data | 1.55 |
| PF3D7_1141300 | PH | NO | NA | 0,12/−3,05 | No data | Plasmodium specific |
| PF3D7_0720700 | PX (PfPX1) | Yes | Yes | 1/−2,65 | No data | Plasmodium specific |
| PF3D7_0704400 | PX | NO | NA | 0,26/−2,77 | No data | −0,86 |
| PF3D7_0311300 | PI(3,4)K Class II | NO | NA | 0.13/−2.97 | Slow growth | −3,91 |
| PF3D7_0515300 | PI3K | NO | NA | 0,24/−2,67 | NO | −3,88 |
| PF3D7_0110600 | PI4,5K | NO | NA | 0,2/−2,77 | NO | −5,81 |
| PF3D7_1129600 | PI(4,5)K Set7/9 family) | Yes | No | 1/−2,22 | Yes | Plasmodium specific |
| PF3D7_0419900 | PI4K Class III alpha | NO | NA | 0,12/−3,01 | Slow growth | Plasmodium specific |
| PF3D7_0509800 | PI4K Class III beta | NO | NA | 0,13/−3,01 | NO | −3,6 |
| PF3D7_1354200 | Sac1 (PfSAC1) | NO | NA | 1/−1,87 | No data | −1,35 |
| PF3D7_1111600 | I5P_5 | Yes | Yes | 0,12/−2,89 | No data | 0,51 |
| PF3D7_0705500 | Sac1-I5P_5 | NO | NA | 0,14/−2,89 | NO | Plasmodium specific |
| PF3D7_0802500 | Sac1 | NO | NA | 0,95/−2,86 | Yes | Not in Tg |
| PF3D7_1315600 | PIP synthase | NO | NA | 0,13/−3,21 | No data | −3,57 |
aTGD, targeted gene disruption; NA, not applicable; MIS, mutagenesis index score; MFS, mutagenesis fitness score.