TABLE 2.
Selected 7-TM GPCRs suitable for Y2H library design
| Receptor name |
UniProt reference accession no. (R)a |
Size (kDa) |
Ligand name(s) | Ligand size(s) (kDa) |
UniProt reference accession no. (L)a |
Family name |
|---|---|---|---|---|---|---|
| CXCR4 | P61073 | 352 | SDF-1α | 65 | P48061 | Chemokine receptors |
| PAR2 | P55085 | 397 | Serine proteases | >100 | Proteinase-activated receptors | |
| V3A receptor | P30518 | 371 | Arg-vasopressin | 9 | P01185 | Vasopressin and oxytocin receptors |
| CCR5 | P51681 | 352 | CCL11, -14, -16, -2, -3, -4, -5, -7, -8 | 74 | P51671 | Chemokine receptors |
| ETB receptor | P24530 | 442 | Endothelin-1, -2, -3 | 21 | P05305, P20800, P14138 | Endothelin receptors |
| MC1 receptor | Q01726 | 317 | α-MSH | 13 | P01189 | Melanocortin receptors |
| ACKR3 | P25106 | 362 | CXCL11, SDF-1α | 70 | O14625, P48061 | Chemokine receptors |
| PTH1 receptor | Q03431 | 593 | PTH, PTHrP | 84, 141 | P01270, P12272, P12272 | Parathyroid hormone receptors |
| Kisspeptin receptor | Q969F8 | 398 | Kisspeptin-10, -13, -14, -52, -54 | 10–54 | Q15726 | Kisspeptin receptor |
| CT receptor | P30988 | 508 | Calcitonin, amylin | 32, 37 | P01258, P10997 | Calcitonin receptors |
| CCR2 | P41597 | 374 | CCL2 | 76 | P13500 | Chemokine receptors |
| GnRH receptor | P30968 | 328 | GnRH I, GnRH II | 10 | P01148, O43555 | Gonadotrophin-releasing hormone receptors |
a
The “R” in parentheses stands for receptor, and “L” stands for ligand.