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Inactivation activity of DL35D against HIV-1 primary isolates and T20-resistant strains (EC50)
| Virus isolates | mD1.22 (nmol/L) | D5 scFv (nmol/L) | DL35D (nmol/L) |
|---|---|---|---|
| Primary HIV-1 isolates | |||
| 92UG029 (A, X4) | 5.46 ± 1.31 | >250 | 5.22 ± 2.02 |
| 92UG024 (D, X4) | 13.50 ± 4.46 | >250 | 3.92 ± 1.28 |
| 93BR020 (F, X4/R5) | 2.70 ± 0.75 | >250 | 2.78 ± 1.02 |
| T20-resistant virus (HIV-1NL4-3 [36G]) | |||
| Parental | 1.30 ± 0.59 | >250 | 1.03 ± 0.34 |
| V38A | 1.97 ± 0.47 | >250 | 2.03 ± 1.05 |
| V38A/N42D | 1.45 ± 0.41 | >250 | 0.60 ± 0.05 |
