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. 2022 Jan 18;13(1):e03618-21. doi: 10.1128/mbio.03618-21

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Copyright © 2022 Beres et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — Acquisition of an SDSE-like pbp2x gene by horizontal gene transfer. (A and B) Genome-wide density of SNPs identified in sample ERR2650320 (aka SAME3198851) relative to Emm1 reference strain MGAS2221 (A) and in the region surrounding pbp2x (B). SNP density is greatest in the region encompassing pbp2x and is significantly greater than the genome average. (C) Gene content in the pbp2x region of elevated SNP density. The region highlighted in yellow indicates the ∼9-kb recombinant segment with an elevated SNP density. The seven genes: proB-proA-(MGAS2221_1384)-mraW-ftsL-pbp2x-mraY have 100% nucleotide identity with the cognate genes of SDSE strain NCTC11554, consistent with HGT acquisition from an SDSE donor. SDSE, Streptococcus dysgalactiae subsp. equisimilis.