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Genetic relationships among S. pyogenes PBP2B recombinant genomes. (A) Genetic relationships among 18 S. pyogenes isolates that have acquired a PBP2B xenologue. Phylogeny was inferred by neighbor-network analysis based on 44,114 core chromosomal SNPs identified relative to Emm1 reference strain MGAS2221. (B) Mean pairwise core SNP genetic distance between the eight different genetic lineages of the PBP2B recombinant isolates. C, cluster designation.
