TABLE 4:
Grade 3 and Higher Toxicity data for all patients.
| Treatment | |||
|---|---|---|---|
| TEM+IRIN (N=53) | TEM+IRIN+BEVA (N=52) | ||
| % | % | ||
| Organ systems | Toxicity Type | 98.1 | 98.1 |
| None | |||
| Gastrointestinal | Abdominal pain | 3.8 | 1.9 |
| Colitis | 1.9 | ||
| Diarrhea | 18.9 | 28.8 | |
| Mucositis oral | 1.9 | ||
| Nausea | 3.8 | 1.9 | |
| Stomach pain | 1.9 | ||
| Typhlitis | 1.9 | ||
| Vomiting | 9.4 | 1.9 | |
| Investigations | Alanine aminotransferase increased | 5.7 | 5.8 |
| Aspartate aminotransferase increased | 1.9 | ||
| Blood bilirubin increased | 1.9 | ||
| GGT increased | 3.8 | ||
| Lymphocyte count decreased | 11.3 | 19.2 | |
| Neutrophil count decreased | 30.2 | 46.2 | |
| Platelet count decreased | 24.5 | 38.5 | |
| White blood cell decreased | 18.9 | 28.8 | |
| Immune | Allergic reaction | 1.9 | |
| Blood/Lymphatic | Anemia | 13.2 | 13.5 |
| Blood and lymphatic system disorders - Other, specify | 1.9 | ||
| Febrile neutropenia | 7.5 | 9.6 | |
| Metabolism/Nutrition | Anorexia | 5.7 | 3.8 |
| Dehydration | 7.5 | 7.7 | |
| Hypercalcemia | 1.9 | ||
| Hyperuricemia | 1.9 | ||
| Hypoalbuminemia | 5.7 | ||
| Hypocalcemia | 1.9 | ||
| Hypokalemia | 3.8 | 7.7 | |
| Hyponatremia | 5.8 | ||
| Hypophosphatemia | 3.8 | ||
| Infections/Infestations | Catheter related infection | 1.9 | |
| Enterocolitis infectious | 3.8 | 1.9 | |
| Infections and infestations - Other, specify | 3.8 | ||
| Sepsis | 9.4 | 1.9 | |
| Skin infection | 1.9 | ||
| Urinary tract infection | 1.9 | ||
| General/Administration | Fatigue | 1.9 | |
| Fever | 1.9 | ||
| Non-cardiac chest pain | 1.9 | ||
| Vascular | Hypertension | 1.9 | |
| Hypotension | 3.8 | ||
| Psychiatric | Personality change | 1.9 | |
| Suicidal ideation | 1.9 | ||
| Renal/Urinary | Proteinuria | 1.9 | |
| Skin/Subcutaneous | Rash maculo-papular | 1.9 | 1.9 |
| Nervous | Seizure | 1.9 | |