Figure 1:

(A) Schematic of dynamic supramolecular interactions used for in situ association, leveraging complementary motifs with one attached to an entity for pre-targeting and another attached to the desired agent to be delivered. (B) Generalized overview of this two-component approach to targeting via in situ complex formation. (C) Examples of common covalent bioorthogonal reactions used in pre-targeting applications for in situ covalent bond formation. (D) Overview of the dynamic supramolecular motifs described herein, which form association complexes through non-covalent molecular recognition.