Hannum’s intrinsic epigenetic age acceleration in controls vs. pre-symptomatic dementia, stratified by sex; Left: Male controls (n = 37, IEAA.Hannum = −0.70) vs. pre-symptomatic dementia participants (n = 31, IEAA.Hannum = +1.12), p = 0.03; Right: Female controls (n = 50, IEAA.Hannum = +0.35) vs. pre-symptomatic dementia participants (n = 42, IEAA.Hannum = −0.31), p = 0.43; Error bars represent standard deviation.