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. Author manuscript; available in PMC: 2022 Jan 18.
Published in final edited form as: Curr Alzheimer Res. 2021;18(5):443–451. doi: 10.2174/1567205018666210823100721

Table 2.

Epigenetic age and age acceleration in pre-symptomatic dementia cases compared to controls.

- Dementia (n = 73) Controls (n = 87) P
Epigenetic age measure Mean epigenetic age in years (SD) -
Horvath 73.2 (6.6) 72 (5.8) 0.22
Hannum 62.3 (6.0) 61.2 (5.8) 0.24
PhenoAge 62.4 (7.5) 60.7 (7.1) 0.14
GrimAge 71.4 (5.2) 70.3 (4.9) 0.75
Age acceleration measure Mean age acceleration in years (SD) -
AgeAccel Horvath +0.32 (4.9) +0.30 (4.5) 0.98
AgeAccel Hannum +0.32 (4.6) +0.20 (4.5) 0.86
IEAA.Horvath +0.13 (4.5) +0.06 (4.1) 0.91
IEAA.Hannum +0.30 (3.9) -0.10 (3.6) 0.50
EEAA +0.32 (5.8) +0.39 (6.3) 0.94
AgeAccel Pheno +0.47 (6.2) +0.02 (5.5) 0.62
AgeAccel Grim +0.09 (3.1) +0.01 (3.0) 0.87

Abbreviations: AgeAccel Grim: age acceleration calculated using epigenetic GrimAge, AgeAccelPheno: age acceleration calculated using epigenetic PhenoAge, AgeAccel Hannum: age acceleration calculated using Hannum epigenetic age, AgeAccel Horvath: age acceleration calculated using Horvath epigenetic age, EEAA: extrinsic epigenetic age acceleration, IEAA.Hannum: intrinsic epigenetic age acceleration calculated using Hannum epigenetic age, IEAA.Horvath: intrinsic epigenetic age acceleration calculated using Horvath epigenetic age; ‘+’ indicates increased epigenetic age compared to chronological age.