Table 4.
Correlations of galectin-3 (ln) and ST2 (ln) with the echocardiographic parameters of the RV and RA size and mechanics in SSc patients
| Parameter | Value | Correlations with ln galectin-3 | Correlations with ln galectin-3, corrected for age |
Correlations with ln ST2 | Correlations with ln ST2, corrected for age |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| r | p | r | p | r | p | r | p | |||
| Pulmonary artery systolic pressure (mm Hg) | 28.6 ± 7.5 | 0.225 | 0.251 | 0.260 | 0.191 | −0.174 | 0.375 | −0.188 | 0.348 | |
| RV basal diameter index (mm/m2) | 18.3 ± 2.4 | −0.254 | 0.119 | −0.253 | 0.126 | −0.015 | 0.928 | −0.015 | 0.928 | |
| RV mid-cavity diameter index (mm/m2) | 13.0 ± 2.1 | −0.169 | 0.311 | −0.169 | 0.318 | −0.037 | 0.827 | −0.037 | 0.828 | |
| RV longitudinal diameter index (mm/m2) | 30.0 ± 3.6 | −0.011 | 0.948 | −0.011 | 0.948 | −0.342 | 0.135 | −0.341 | 0.148 | |
| Inferior vena cava (mm) | 13.2 ± 3.9 | −0.053 | 0.765 | −0.052 | 0.775 | −0.255 | 0.146 | −0.254 | 0.153 | |
| Collapsibility index (%) | 55.2 ± 10.7 | 0.134 | 0.449 | 0.134 | 0.457 | −0.131 | 0.462 | −0.132 | 0.465 | |
| RV wall thickness (mm) | 5.1 ± 1.2 | −0.091 | 0.597 | −0.106 | 0.545 | −0.051 | 0.766 | −0.086 | 0.622 | |
| RV fractional area change (%) | 47.9 ± 6.8 | −0.138 | 0.423 | −0.142 | 0.415 | −0.001 | 0.997 | 0.013 | 0.943 | |
| Tricuspid annular plane systolic excursion (mm) | 21.4 ± 2.6 | −0.249 | 0.121 | −0.243 | 0.136 | 0.315 | 0.248 | 0.321 | 0.284 | |
| Grade of tricuspid regurgitation | Mild n (%) | 38 (95%) | 0.168 | 0.307 | 0.165 | 0.321 | −0.105 | 0.523 | − 0.105 | 0.530 |
| Moderate n (%) | 2 (5%) | |||||||||
| Severe n (%) | 0 (0%) | |||||||||
| Tricuspid E cm/s | 47.4 ± 8.0 | −0.073 | 0.658 | −0.087 | 0.602 | −0.060 | 0.751 | −0.050 | 0.767 | |
| Tricuspid A cm/s | 40.1 ± 8.5 | 0.371 | 0.020 | 0.372 | 0.022 | −0.160 | 0.330 | −0.162 | 0.331 | |
| Tricuspid S (cm/s) | 12.4 ± 2.0 | −0.170 | 0.293 | −0.169 | 0.305 | 0.363 | 0.221 | 0.363 | 0.227 | |
| Tricuspid e’ (cm/s) | 10.0 ± 2.8 | −0.038 | 0.817 | −0.009 | 0.956 | 0.006 | 0.972 | 0.001 | 0.996 | |
| Tricuspid a’ (cm/s) | 13.1 ± 2.9 | −0.100 | 0.539 | −0.147 | 0.372 | 0.154 | 0.342 | 0.182 | 0.267 | |
| Tricuspid E/e’ ratio | 5.2 ± 1.6 | 0.003 | 0.985 | 0.004 | 0.983 | −0.001 | 0.995 | −0.008 | 0.963 | |
| RA Vmax index (mL/m2) | 19.9 ± 5.8 | −0.013 | 0.947 | 0.017 | 0.929 | −0.048 | 0.800 | −0.101 | 0.602 | |
| RA Vmin index (mL/m2) | 8.1 ± 4.0 | 0.227 | 0.227 | 0.245 | 0.201 | −0.136 | 0.473 | −0.163 | 0.397 | |
| RA Vp index (mL/m2) | 14.3 ± 5.5 | 0.058 | 0.760 | 0.083 | 0.668 | −0.112 | 0.555 | −0.156 | 0.419 | |
| RA reservoir strain (%) | 45.3 ± 9.0 | −0.239 | 0.167 | −0.236 | 0.179 | 0.218 | 0.209 | 0.229 | 0.193 | |
| RA conduit strain (%) | 24.2 ± 6.4 | −0.213 | 0.220 | −0.210 | 0.233 | 0.199 | 0.253 | 0.220 | 0.212 | |
| RA contractile strain (%) | 22.0 ± 6.1 | −0.220 | 0.204 | −0.231 | 0.188 | 0.065 | 0.713 | 0.056 | 0.753 | |
Statistically significant p-values are formatted in bold (p < 0.05)