Figure 2.

Images acquired in a model of lung cancer, a) before, and b) after administration of GNE140. From the left: ¹³C MRSI voxels overlaid onto proton; representative ¹³C spectra from the tumor; pyruvate; and lactate, images. A vial of acetate used for reference (located approximately 50Hz from lactate in ¹³C spectra) appears in proton and lactate images to the left of the mouse. The signal intensity in the lactate image from ¹³C MRSI post administration of the LDH inhibitor is multiplied by 3 (relative to signal in the pyruvate image) to highlight the absence of lactate signal. c) Scatter plots show the change in lactate-to-pyruvate ratios from hyperpolarized ¹³C MRSI in the EFGR-driven lung cancer tumors before and after administration of vehicle (left) and GNE140 (right). N=3 for both control and treated groups.