Figure 3.

Images acquired in a model of lung cancer, a) before, and b) after administration of tamoxifen to initiate LDH-A deletion. From the left: ¹³C MRSI voxels overlaid onto proton; representative ¹³C spectra from the tumor; pyruvate; and lactate, images. Pyruvate and lactate images from the same ¹³C MRSI acquisition are displayed on the same scale. c) Scatter plot shows the change in lactate-to-pyruvate ratios from hyperpolarized ¹³C MRSI in the lung cancer model before and after administration of tamoxifen to initiate LDH-A deletion.