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. 2022 Jan 18;21:20. doi: 10.1186/s12943-021-01490-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — PD-L1⁺EVs and PD1⁺ EVs from melanoma and T cells of responders and non-responders enrolled in the validation cohort. A Scatter plots with median of the percentage of PD-L1⁺ EVs from melanoma and PD1⁺ EVs from CD8 T cells isolated from responders (9) and non-responders (13) enrolled in the validation independent cohort (Mann Whitney t test **p < 0.05, *** p < 0.001). B Kaplan–Meier survival curve analysis according to PD-L1⁺ EVs quartiles, with PD-L1⁺EVs from melanoma as respect to PFS, and according to PD1⁺ EVs quartiles, with PD1⁺EVs from T cells as respect to PFS. C Univariable Cox-hazard regression analysis (PFS)