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. 2022 Jan 18;20:12. doi: 10.1186/s12916-021-02207-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — a CNS time to progression in three cohorts. With a median follow-up of 19.2 months, 22.5 months, and 15.8 months in these three cohorts respectively, CNS TTP was NE vs 33.0 m vs NE. b Intracranial duration of response in three cohorts. With median follow-up of 18.7 months, 22.7 months, and 16.8 months in these three cohorts respectively, ic-DOR was NE vs NE vs NE. c CNS TTP in patients with uncontrolled CNS metastases. With a median follow-up of 19.0 months, 22.6 months, and 12.3 months in these three cohorts respectively, CNS TTP was NE vs 33.0 m vs NE