Table 5.

Treatment of mannitol or corticosteroids before or after the administration of alectinib

Patients with CNS-related symptoms in the baseline, n = 28	Before the initiation of alectinib	After the treatment of alectinib
Number of patients who needed mannitol or corticosteroids	18 (64.3%)	3 (10.7%)
Number of patients who didn't need mannitol or corticosteroids	10 (35.7%)	25(89.3%)

Fisher exact test: p < 0.001, the number of patients who were in need of mannitol or corticosteroids decreased remarkably after the treatment of alectinib