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. 2022 Jan 18;8:1. doi: 10.1186/s40959-021-00127-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Differences between groups based upon percent-predicted peak exercise O₂ pulse or median LV ECVF. Legend: Box and whisker plots (Panels A-F) demonstrating median (horizontal line within rectangular box), interquartile range, whiskers, and range between groups based upon %O₂ pulse (< or ≥ 85%). Panel A: Lower SVI in those with peak O₂ pulse < 85% of predicted. Panel B: Lower LVEF in those with a peak O₂ pulse < 85% of predicted. Panel C: Lower peak VO₂ in those with a peak O₂ pulse < 85% of predicted. Panel D: Higher LV ECVF in those with a peak O₂ pulse < 85% of predicted. Panel E: Higher NTproBNP levels in those with a peak O₂ pulse < 85% of predicted. Panel F: Trend towards higher V10Gy in those with a peak O₂ pulse < 85% of predicted. Panel G: Lower resting LVEF in those with LV ECVF values >median. Panel H: Lower peak %O₂ pulse values in those with LV ECVF >median. Abbreviations: SVI = stroke volume index; O₂ = oxygen; LVEF = left-ventricular ejection fraction; VO₂ = oxygen consumption; ECVF = extracellular volume fraction; NTproBNP=N-terminal pro-brain natriuretic peptide; V10Gy = %volume of heart receiving ≥10 Gray