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. 2022 Jan 18;12(1):e706. doi: 10.1002/ctm2.706

TABLE 1.

Cellular processes associated with OIP5‐AS1 function in human disease

Disorder Cellular process Mediators Model References
Acute lung injury Proliferation, apoptosis, oxidative stress response, inflammatory response miR‐223, NLRP3, miR‐26a‐5p, TLR4 Cell lines, animal models 180 , 181
Asthma Apoptosis regulation, inflammatory response, miRNA regulation miR‐143‐3p, HMGB1 Cell lines, clinical specimens 79 , 80
Atherosclerosis miRNA regulation, apoptosis regulation miR‐320a, LOX1 Cell lines and clinical specimens 98
Bipolar disorder Unknown, potential biomarker based on expression Unknown Cell lines and clinical specimens 83
Cataracts Apoptosis, oxidative stress HuR, POLG Cell lines 73
Cardiac failure Mitochondrial function, stress response in female animals Unknown Cell lines and animal models 109
Diabetic nephropathy Apoptosis, proliferation, fibrosis miR‐34a‐5p, Sirt1, HIF‐1α Cell lines and animal models 54
Diabetic angiopathy Apoptosis, cognitive function miR‐200b, ACE2 Cell lines and animal models 57
Diabetic retinopathy Apoptosis miR‐449c Cell lines and clinical specimens 59
Intervertebral disk degeneration Proliferation, extracellular matrix accumulation Unknown Cell lines and clinical specimens 72
Myocardial ischaemia Apoptosis miR‐297a, CGRP, miR‐29a, SIRT1 Cell lines and animal models 2 , 62
Osteoarthritis Inflammatory response regulation, apoptosis, migration, proliferation miR‐30a‐5p, miR‐29b‐3p, PGRN Cell lines and clinical specimens 66 , 182
Periodontitis Inflammatory response Unknown Cell lines and clinical specimens 76
Parkinson's disease Alpha‐synuclein toxicity and aggregation, apoptosis, autophagy, endoplasmic reticulum stress miR‐126 Cell lines and clinical specimens 92
Rheumatoid arthritis Inflammatory response regulation, apoptosis miR‐448, PON1 Cell lines and clinical specimens 65
Schizophrenia Disease predictor in females Unknown Cell lines and clinical specimens 22

Abbreviations: CGRP, calcitonin gene‐related peptide; LOX1, lectin‐like oxidised low‐density lipoprotein 1; PGRN, progranulin; PON1, paraoxonase 1; Sirt1, silent information regulator T1.