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. 2021 Dec 30;23(2):182. doi: 10.3892/etm.2021.11105

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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HSYA regulates the expression level of collagen-associated proteins in NP cells via CA XII. (A) Western blot analysis was used to detect the protein expression level of CA XII and the results were (B) statistically analyzed. Immunocytochemistry was used to detect the protein expression level of (C) aggrecan, (D) collagen II and (E) MMP-13. (F) Western blot analysis was used to detect the protein expression level of ECM-related proteins and the results were statistically analyzed for (G) MMP-13, (H) aggrecan and (I) collagen II. ^*P<0.05, ^**P<0.01 vs. control; ^##P<0.01 vs. model. CA XII, carbonic anhydrase 12; HSYA, hydroxysafflor yellow A; si, small interfering.