Table 2.
Main findings of studies published since the year 2000 that have evaluated the efficacy of LD-RT for degenerative or inflammatory musculoskeletal disorders
| Author & year | Type of study | N | Total dose (dose per fraction) | MFU (months) |
|---|---|---|---|---|
| Painful shoulder syndrome: periarthritis humeroscapularis | ||||
| Schultze 200413 | Retrospective | 94 | 6 Gy (0,75 Gy) | 4 |
| Niewald 200714 | Retrospective | 141 | 4–8 Gy (0.5–7 Gy) & Gy (1 Gy): 89% | 47 |
| Adamietz 201015 | Retrospective | 102 | 3 Gy (0.5 Gy) x two series | 18 |
| Ott 201416 | Randomized | 312 | 3 Gy (0.5 Gy) (51%) 6 Gy (1 Gy) (49%) | 35 |
| Micke 201817 | Retrospective | 162 | 12 × 0.5 Gy (74%) 6 × 1 Gy (26%) | 42 |
| Painful elbow syndrome: epicondylitis humeri | ||||
| Ott 201419 | Randomized | 216 | 3 Gy (0.5 Gy) (52%) 6 Gy (1 Gy) (48%) | 35 |
| Leszek 201520 | Retrospective | 50 | 6 Gy (1 Gy) | 12 |
| Hautmann 201921 | Retrospective | 138 | 3 Gy (0.5 Gy) (9.4%) 6 Gy (1 Gy) (89.9%) Other (0.8%) | 29 |
| Hautmann 202022 | Retrospective | 99 | Reirradiation: 3 Gy (0.5 Gy) (62.6%) 6 Gy (1 Gy) (37.4%) | 28 |
| Finger joint osteoarthritis | ||||
| Kaltenborn 201625 | Retrospective | 84 | 6 Gy (1 Gy) | 3 |
| Minten 201826 | Randomized | 56 | 6 × 1 Gy vs Sham radiotherapy | 3 |
| Alvarez 202027 | Prospective | 51 (25 rizarthrosis; 26 other finger joint osteoarthritis) | 6 Gy (1 Gy) | 8 |
| Rogers 202028 | Retrospective | 99 | 4 Gy (0.5 Gy) | NE |
| Trochanteric bursitis | ||||
| Valduvieco 201632 | Retrospective | 60 | 10 Gy (1 Gy) | 18.5 |
| Kaltenborn 201733 | Retrospective | 60 | 3 Gy (0.5 Gy) (39%) 6 Gy (1 Gy) (61%) | 18 |
| Micke 201817 | Retrospective | 70 | 12 × 0.5 Gy (94%) 6 × 1 Gy (4%) | 29 |
| Gonarthrosis | ||||
| Glatzel 200237 | Retrospective | 114 | 3–6 Gy (median, 6 Gy) (0.5–1 Gy, median 1 Gy) | 29 |
| Mucke 201038 | Retrospective | 4544 | Total dose: 3–12 Gy (median 6 Gy) Dose/fraction: 0.25–3 Gy (median 1 Gy) | NE |
| Keller 201339 | Retrospective | 1037 | Total dose: 0.5–10 Gy (median 4 Gy) Dose/fraction: 0.5–1.5 Gy (median 1 Gy) | NE |
| Micke 201817 | Retrospective | 139 | 12 × 0.5 Gy (80.6%) 6 × 1 Gy (19.4%) | 19.5 |
| Mahler 201940 | Randomized | 55 | 6 × 1 Gy vs Sham radiotherapy | 3 |
| Plantar fasciitis and Achiles tendinopathy | ||||
| Glatzel 200143 | Retrospective | 141 | 6 Gy (1 Gy) | 30 |
| Schneider 200444 | Retrospective | 62 | 5 Gy (0.25 Gy-1 Gy) | 40 |
| Muecke 200746 | Retrospective | 502 | 5–6 Gy (0.5–1 Gy) | 26 |
| Heyd 200747 | Randomized | 130 | 3 Gy (0.5 Gy) (50%) 6 Gy (1 Gy) (50%) | 6 |
| Hajtmanova 201048 | Retrospective | 323 | 4 Gy (1 Gy) | 3 |
| Niewald 201249 | Randomized | 62 | 0.6 Gy (0.1 Gy) (53%) 6 Gy (1 Gy) (47%) | 12 |
| Hermann 201350 | Retrospective | 250 | 3 Gy (0.5 Gy) (18%) 6 Gy (1 Gy) (72%) | 11 |
| Koca 201451 | Retrospective | 62 | 8 Gy (4 Gy) | 28 |
| Badakhshi 201452 | Retrospective | 171 | 3 Gy (0.5 Gy) | 54 |
| Uysal 201453 | Retrospective | 450 | 8 Gy (4 Gy) | 12 |
| Canyilmaz 201534 | Randomized | 124: 60 RT 64 Injection CE + AN | 6 Gy (1 Gy) vs Injection CE + AN | 12.5 |
| Niewald 201554 | Randomized | 117 | 6 Gy (1 Gyx6) vs 6 Gy (0.5 Gyx12) | 3 |
| Ott 201455 | Randomized | 457 | 3 Gy (0.5 Gy) (46%) 6 Gy (1 Gy) (54%) | 32 |
| Micke 201817 | Retrospective | 286 | 6 Gy (0.5 Gy) (92.6%) 6 Gy (1 Gy) (7.4%) | 34 |
| Ott 201556 | Randomized (Achilles tendinopathy) | 112 | 6 Gy (0.5 Gy) 6 Gy (1 Gy) | 24 |