Table 1.

Pooled prevalence of proportion of various clinical presentations described among COVID-19-associated rhino-orbito-cerebral mucormycosis patient population

Clinical feature	Number of studies/reference	Event/total	Pooled data		SE	Over all P	Heterogeneity
			Pooled proportion	95% CI			I2 (%)	Tau 2/Q/DF	Heterogeneity P
Clinical feature
Loss of vision	10[6,14,25,26,27,29,35,38,39,44]	71/141	0.537	0.282-0.793	0.130	<0.001	93	0.151/147.530/9	<0.001
Lid edema	9[25,26,29,31,34,35,37,39,43]	35/70	0.515	0.278-0.751	0.121	<0.001	84	0.105/52.026/8	<0.001
Ophthalmoplegia	8[14,29,30,31,35,37,38,43]	66/107	0.573	0.395-0.751	0.091	<0.001	72	0.042/25.310/7	<0.001
Proptosis	8[14,26,29,35,37,38,39,43]	56/95	0.606	0.385-0.826	0.112	<0.001	87	0.082/56.483/7	<0.001
Facial edema	6[29,34,35,37,39,43]	19/52	0.347	0.216-0.477	0.067	<0.001	9	0.003/5.514/5	<0.001
Palatal involvement	3[26,29,44]	13/21	0.575	0.162-0.989	0.211	0.006	79	0.104/9.717/2	0.008
Ptosis	4[14,26,29,39]	26/37	0.727	0.534-0.920	0.099	<0.001	53	0.020/6.458/3	0.091
Pupil involvement	3[14,26,31]	11/19	0.581	0.362-0.801	0.112	<0.001	0	0.000/0.356/2	0.837
Palatal Eschar	6[26,29,34,35,38,44]	20/74	0.356	0.058-0.654	0.152	0.019	91	0.120/59.771/5	<0.001
Optic nerve involvement	2[34,35]	4/17	0.230	0.031-0.430	0.102	0.023	0	0.000/0.163/1	0.687
Nasal blockage	2[29,39]	3/25	0.118	−0.008-0.244	0.064	0.067	0	0.000/0.067/1	0.796
Radiological feature
Sinonasal involvement	4[24,38,39,43]	47/79	0.549	−0.013-1.11	0.287	0.056	98	0.319/235.393/3	<0.001
Rhino-orbital involvement	8[7,14,26,31,37,39,43,44]	165/259	0.708	0.539-0.877	0.086	<0.001	87	0.044/57.998/7	<0.001
Intracranial spread	13[6,7,14,24,25,26,27,29,32,35,37,39,44]	103/333	0.428	0.297-0.560	0.067	<0.001	82	0.042/69.656	<0.001
Involvement of orbital apex	2[14,34]	8/21	0.257	−168-0.882	0.268	0.183	89	0.129/9.578/1	0.002
Involvement of cavernous sinus	8[26,29,30,31,32,37,38,39]	36/132	0.403	0.22-0.595	0.098	<0.001	88	0.059/60.787/7	<0.001

CI=Confidence interval, SE=Standard error