Table 2. . Role and mechanism of exosome-derived RNA in cartilage regeneration.
| Exosomes component | Donor cell | Target cell | Induced mechanism | Ref. |
|---|---|---|---|---|
| miR-216-5p | BMSC | Chondrocyte | Enhance chondrocyte proliferation, migration and apoptosis repression | [62] |
| lncRNA H19 | UMSC | Chondrocyte | Promote proliferation and prevent apoptosis in chondrocytes | [61] |
| miR-8485 | Chondrocyte | BMSC | Promote chondrogenic differentiation of BMSCs | [96] |
| mir-145 and mir-221 | ADSC | Chondrocyte | Promote proliferation | [97] |
| miR-100-5p | IPF-MSC | Chondrocyte | Inhibit mTOR autophagy pathway | [72] |
| miR-92a-3p | BMSC | Chondrocyte, MSC | Promote chondrocyte proliferation and matrix genes expression | [101] |
ADSC: Adipose-derived stem cell; BMSC: Bone marrow mesenchymal stem cell; IPF-MSC: Infrapatellar fat pad mesenchymal stem cell; MSC: Mesenchymal stem cell; UMSC: Umbilical cord mesenchymal stem cell.