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. 2022 Jan 4;12:768318. doi: 10.3389/fpsyt.2021.768318

Table 2.

Drinking, craving, and depression outcomes at beginning and end of treatment.

Desipramine Paroxetine Time Naltrexone Placebo Time
Mean (SE) Mean (SE) F, p Mean (SE) Mean (SE) F, p
Drinking Outcomes
% Number of drinking days
Pre 55.6 (5.03) 62.58 (4.48) 218.49, 0.00 62.60 (4.70) 58.14 (4.82) 226.39, 0.00
Post 7.62 (2.1) 9.36 (1.92) 9.32 (2.01) 7.31 (2.06)
% Heavy drinking days
Pre 50.3 (5.19) 56.84 (4.62) 156.8, 0.00 54.10 (4.85) 54.99 (4.97) 162.89. 0.00
Post 7.09 (2.38) 9.29 (2.12) 8.55 (2.24) 6.95 (2.29)
Drinks per drinking days
Pre 17.03 (1.81) 15.69 (1.61) 53.57, 0.00 16.34 (1.66) 16.74 (1.70) 57.71, 0.00
Post 4.19 (1.82) 7.55 (1.62) 6.01 (1.71) 5.15 (1.75)
Craving Outcomes
OCDS (total scores)
Pre 19.00 (1.76) 19.92 (1.57) 8.84, 0.00 19.93 (1.56) 19.94 (1.63) 10.1, 0.00
Post 8.08 (1.55) 8.66 (1.40) 7.18 (1.43) 8.44 (1.37)
Depression Outcomes
HAM-D (17 items)
Pre 11.72 (0.74) 11.66 (0.65) 7.99, 0.00 11.89 (0.69) 11.26 (0.69) 8.16, 0.00
Post 8.18 (0.83) 7.61 (0.73) 7.81 (0.75) 7.56 (0.74)

HAM-D, Hamilton Depression Rating Scale; OCDS, Obsessive Compulsive Drinking Scale.