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Fosfo facilitates synergistic killing significantly with DAP against DAP-S/DAP-R MRSA strains in an ex vivo IE model within simulated IE vegetations. Simulated model doses were DAP at 6 mg/kg every 24 h and/or Fosfo at 4 g every 8 h. *, P ≤ 0.05 for DAP+Fosfo versus the single antibiotics in both the DAP-S and DAP-R strains. Arrows highlight the increased bactericidal synergistic killing impact of combination of DAP and Fosfo versus those of the single antibiotics.
