TABLE 2.
Treatment of DAP-R CB185 with DAP+Fosfoa
| Treatment group (5 rabbits/group) | Vegetation count (mean CFU/g ± SD) | Kidney count (mean CFU/g ± SD) | Spleen count (mean CFU/g ± SD) |
|---|---|---|---|
| Untreated | 8.28 ± 0.6 | 6.49 ± 0.5 | 6.55 ± 0.3 |
| DAP alone (2 mg) | 8.80 ± 0.2 | 7.88 ± 0.5 | 6.74 ± 0.3 |
| DAP alone (6 mg) | 8.62 ± 0.6 | 7.86 ± 0.6 | 6.80 ± 0.4 |
| DAP alone (10 mg) | 8.99 ± 0.4 | 7.81 ± 0.1 | 6.57 ± 0.9 |
| Fosfo alone (300 mg) | 5.95 ± 1.3 * | 3.53 ± 0.7 * | 3.65 ± 1.0 * |
| DAP (2 mg) + Fosfo (300 mg) | 6.84 ± 1.1 α | 2.71 ± 1.2 α | 2.61 ± 0.8 α |
| DAP (6 mg) + Fosfo (300 mg) | 7.44 ± 0.2 β | 3.70 ± 1.2 β | 3.05 ± 1.0 β |
| DAP (10 mg) + Fosfo (300 mg) | 1.98 ± 1.2 $ + | 1.07 ± 0.4 $ ++ | 0.87 ± 0.1 $ +++ |
a
*, P < 0.01 versus untreated control, DAP alone (2 to 10 mg); β, P < 0.05 versus untreated control, DAP alone (2 to 10mg); α, P < 0.01 versus untreated control, DAP alone (2 to 10 mg), Fosfo alone (300 mg), and DAP (2 mg) plus Fosfo (300 mg); $, P < 0.001 versus untreated control, DAP alone (2 to 10 mg), Fosfo alone (300 mg), and DAP (6 mg) plus Fosfo (300 mg); +, 3/5 animals sterile; ++, 4/5 animals sterile; +++, 5/5 animals sterile.