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. 2022 Jan 17;29(1):316–327. doi: 10.1080/10717544.2022.2026532

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Design of Chol/A10-3.2/siCAT-1/3WJ-pRNA nanoparticles harboring cholesterol, A10-3.2 aptamer and siCAT-1 using 3WJ-pRNA as scaffold. (A) The sequence and secondary structure of 3WJ-pRNA core. aWJ, bWJ, and cWJ represent the three strands of the 3WJ-pRNA complex. (B) Design strategy of Chol/A10-3.2/siCAT-1/3WJ-pRNA nanoparticles harboring cholesterol for NDs-anchoring, A10-3.2 aptamer for PSMA-binding and siCAT-1 for CAT-1 silencing. (C) The detailed sequence and secondary structure of Chol/A10-3.2/siCAT-1/3WJ-pRNA, the 3WJ-pRNA core was boxed.