Table 1.
Strands | Modification | Sequence |
---|---|---|
Strand 1 | aWJ-Cholesterol | 5′-uuGccAuGuGuAuGuGGG-Cholesterol-3′ |
Strand 2 | bWJ-A10-3.2 | 5′-cccAcAuAcuuuGuuGAuccGGGAGGAcGAuGcGGAucAGccA uGuuuAcGucAcuccu-3′ |
Strand 3 | cWJ-siCAT-1 | 5′-GGAucAAucAuGGcAAuuGAcAuAuucGcAGuGAucAuAuu-cy3-3′ |
Strand 4 | siCAT-1 antisense | 5′-UAUGAUCACUGCGAAUAUGUCUU-3′ |
The core sequences of 3WJ-pRNA are shown by underline, lowercase letters indicate 2′-F modified nucleotides.