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. 2022 Jan 17;54(1):211–226. doi: 10.1080/07853890.2021.2011956

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Validation and exploration of the potential prognostic and therapeutic significance of PTTG1 in FUSCC cohort. The expression level of PTTG1 was significantly higher in pRCC tissues compared with adjacent normal tissues in FUSCC cohort (A–C). Survival analyses (D–E) show that elevated expression level of PTTG1 was significantly associated with poorer OS (HR = 2.673, p = .001) and PFS (HR = 2.683, p < .001). The retrospective analysis (F–G) indicated that elevated PTTG1 expression was significantly associated with better ICB response (χ²=3.99, p < .05) and PTTG1 may serve as a stable biomarker for immunotherapy (AUC = 0.679, p = .009).