TABLE 1.
Summary of mean (SD) pharmacokinetic parameters for rezafungin, plasma total radioactivity, and whole blood total radioactivity for human subjectsa
| Parameterb | Plasma rezafungin | Plasma total radioactivity | Whole blood total radioactivity |
|---|---|---|---|
| AUC0-tc | 2050 (137) | 2600 (163) | 2390 (175) |
| AUC0-∞c | 2110 (141) | 2750 (182) | 2450 (200) |
| Cmax (μg/ml) | 18.9 (2.50) | 18.2 (2.28) | 18.5 (2.24) |
| tmax (hours) | 1.00 (1.00, 1.00) | 1.00 (1.00, 1.00) | 1.00 (1.00, 1.00) |
| t½ (hours) | 341 (42.8) | 387 (44.8) | 408 (39.7) |
| CL (liters/hour) | 0.180 (0.131) | NA | NA |
| VZ (liters) | 88.6 (12.0) | NA | NA |
AUC0-t = area under the concentration-time curve from 0 to the last measurable concentration; AUC0-∞ = AUC extrapolated to infinity; Cmax = maximum observed concentration; CL = apparent systemic clearance; max = maximum; min = minimum; SD = standard deviation; tmax = time to maximum observed concentration; t½ = terminal elimination halflife; Vz = apparent volume of distribution based on the terminal elimination phase.
Results are reported as arithmetic mean (SD), except for tmax, which is reported as median (min, max).
Units are μg×hour/ml for rezafungin, μg equivalent×hour/ml for plasma and whole blood total radioactivity.