TABLE 1.
Triazole drug susceptibility and Erg11 profiles of 28 C. auris clade III clinical isolates
| Origin | Isolatea | Specimen | Erg11 | MICb (μg/ml) |
|||
|---|---|---|---|---|---|---|---|
| FLC | VRC | POS | ITC | ||||
| AR bank | AR-0381 | N/A | WT | 4 | 0.03 | <0.03 | 0.03 |
| AR-0382 | N/A | WT | 4 | 0.03 | 0.06 | 0.06 | |
| AR-0383 | N/A | V125A/F126L | >128 | 1 | 0.03 | 0.125 | |
| AR-0384 | N/A | V125A/F126L | >128 | 1 | 0.06 | 0.25 | |
| South Africa | SA1 | CVC tip | V125A/F126L | >128 | 1 | 0.125 | 0.25 |
| SA2 | Blood | V125A/F126L | >128 | 0.5 | 0.125 | 0.5 | |
| SA3 | CVC tip | V125A/F126L | >128 | 1 | 0.03 | 0.5 | |
| SA4 | Blood | V125A/F126L | >128 | 1 | 0.03 | 0.5 | |
| SA5 | Tracheal aspirate | V125A/F126L | >128 | 2 | 0.03 | 0.5 | |
| SA6 | Blood | V125A/F126L | >128 | 1 | 0.03 | 0.5 | |
| SA7 | Urine | V125A/F126L | >128 | 1 | 0.125 | 0.5 | |
| SA8 | Urine | V125A/F126L | >128 | 1 | 0.03 | 0.25 | |
| SA9 | Urine | V125A/F126L | >128 | 1 | 0.03 | 0.5 | |
| SA10 | Blood | V125A/F126L | >128 | 1 | 0.125 | 0.5 | |
| SA11 | Blood | V125A/F126L | >128 | 1 | 0.03 | 1 | |
| SA12 | Urine | V125A/F126L | >128 | 1 | 0.03 | 0.25 | |
| SA13 | Urine | V125A/F126L | 8 | 1 | 0.03 | 0.25 | |
| SA14 | Urine | V125A/F126L | >128 | 2 | 0.03 | 0.5 | |
| SA15 | Tracheal aspirate | V125A/F126L | 8 | 1 | 0.03 | 0.5 | |
| SA16 | Tracheal aspirate | V125A/F126L | 8 | 1 | 0.03 | 0.5 | |
| SA17 | Urine | V125A/F126L | >128 | 1 | 0.03 | 0.25 | |
| SA18 | Urine | V125A/F126L | 128 | 0.5 | 0.03 | 0.5 | |
| SA19 | Urine | V125A/F126L | 128 | 2 | 0.03 | 0.25 | |
| SA22 | Urine | V125A/F126L | 128 | 0.5 | 0.25 | 0.5 | |
| SA23 | Urine | V125A/F126L | >128 | 8 | 0.25 | 0.5 | |
| Australia | A3 | Sternum | V125A/F126L | >128 | 1 | 0.25 | 1 |
| A4 | Sternum | V125A/F126L | >128 | 1 | 0.25 | 1 | |
| A6 | Axilla & groin | V125A/F126L | >128 | 0.25 | 0.125 | 1 | |
| A7 | Axilla & groin | V125A/F126L | >128 | 0.25 | 0.25 | 1 | |
| A8 | Catheter specimen of urine (CSU) | V125A/F126L | >128 | 0.5 | 0.25 | 1 | |
aFor reference, susceptibility results are presented for two Erg11 wild-type (WT) strains: AR-0381 (clade II) and AR-0382 (clade I).
bFLC, fluconazole; VRC, voriconazole; POS, posaconazole; ITC, itraconazole.