FIG 1.

Mutations in the HIV-1 3′-polypurine tract (3′PPT) upon in vivo and in vitro dolutegravir (DTG) treatment. 3′PPT sequences observed upon DTG monotherapy (Wijting et al. [2]), upon long-term in vitro culturing with DTG (Malet et al. [3]) and upon a novel in vitro randomization/selection protocol (M1 to M3) are shown. The G stretch that was randomized in the latter analysis is indicated. Nucleotide mutations are indicated in red and underlined (Δ, nucleotide deletion).