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DTG sensitivity of 3′PPT variants. (A) TZM-bl cells were infected with equal amounts of wt and 3′PPT-mutated HIV-1 (0.25 ng CA-p24 virus) and cultured at different DTG concentrations. The Tat-induced luciferase activity was measured at 3 days after infection (n = 2), and average values (± standard error) are plotted. (B) Relative luciferase activity upon infection in the presence of DTG with the activity measured without DTG set at 100%.
