Table 2.
Patients included in HRQoL analyses (n = 379) |
|||||
---|---|---|---|---|---|
Three-arm randomization |
Short-course radiotherapy comparison |
||||
SRT (n = 51) | SRT-delay (n = 57) | LRT-delay (n = 61) | SRT (n = 154) | SRT-delay (n = 164) | |
Age (years) | 64 (35–79) | 63 (41–83) | 65 (40–79) | 65 (35–81) | 64 (39–80) |
Sex | |||||
Men | 33 (64.7%) | 40 (70.2%) | 38 (62.3%) | 94 (61.0%) | 97 (59.1%) |
Women | 18 (35.3%) | 17 (29.8%) | 23 (37.7%) | 60 (39.0%) | 67 (40.9%) |
Height from anal verge (cm) | |||||
0–5 | 20 (39.2%) | 25 (43.9%) | 18 (29.5%) | 53 (34.4%) | 55 (33.5%) |
6–10 | 20 (39.2%) | 20 (35.1%) | 28 (45.9%) | 60 (39.0%) | 60 (36.9%) |
11–15 | 11 (21.6%) | 12 (21.1%) | 15 (24.6%) | 41 (26.6%) | 49 (29.9%) |
Type of surgery | |||||
AR | 33 (64.7%) | 34 (59.6%) | 41 (67.2%) | 98 (63.6%) | 105 (64.0%) |
APE | 17 (33.3%) | 22 (38.6%) | 15 (24.6%) | 50 (32.5%) | 56 (34.1%) |
Hartmann's | 1 (2.0%) | 1 (1.8%) | 3 (4.9%) | 6 (3.9%) | 3 (1.8%) |
LE | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
NR | 0 (0%) | 0 (0%) | 2 (3.3%) | 0 (0%) | 0 (0%) |
yPStage | |||||
I* | 28 (54.9%) | 30 (52.6%) | 23 (37.7%) | 65 (42.2%) | 74 (45.1%) |
II | 14 (27.5%) | 15 (26.3%) | 20 (32.8%) | 49 (31.8%) | 38 (23.2%) |
III | 9 (17.6%) | 10 (17.5%) | 17 (27.9%) | 39 (25.3%) | 44 (26.8%) |
IV | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (0.6%) |
X | 0 (0%) | 2 (3.5%) | 1 (1.6%) | 1 (0.6%) | 7 (4.3%) |
Data are median (range) or n (%).
*Includes patients with complete pathological response. HRQoL, health-related quality of life; SRT, short-course radiotherapy of 5 × 5 Gy, with surgery within 1 week; SRT-delay, short-course radiotherapy of 5 × 5 Gy, with a delay of 4–8 weeks to surgery; LRT-delay, long-course radiotherapy of 25 × 2 Gy, with surgery after 4–8 weeks; AR, anterior resection; APE, abdominal perineal excision; LE, local excision; NR, no resection.