FIG 5.

M. abscessus burden in the lungs of mice. C3HeB/FeJ mice were used. All mice were immunosuppressed with dexamethasone. Lung M. abscessus burden assessments at weeks −1, 0, +1, +2, and +4 (n = 5 per group per time point; represented as mean ± SD) are shown. Week −1 represents the day after mice were infected with M. abscessus, and week 0 represents the day of antibiotic treatment initiation (denoted with vertical dotted line). Data correspond to mice infected with reference strain ATCC 19977 (A), and clinical isolates M9501 (B), M9529 (C), and M9530 (D). PBS, phosphate-buffered saline control; IMI, imipenem; OMC, omadacycline. PBS and OMC (15 mg/kg) were administered once daily, and IMI (200 mg/kg) was administered twice daily. All agents were administered by subcutaneous injection into the dorsal flank.