TABLE 1.
MICs of omadacycline and select antibiotics against 31 M. abscessus clinical isolates and reference strain ATCC 19977 in CAMHB
| Drugb | MIC (µg/mL) against isolate ofa: |
MIC range (µg/mL) | MIC50 (µg/mL) | MIC90 (µg/mL) | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
M. abscessus subsp. abscessus |
M. abscessus subsp. massiliense |
M. abscessus subsp. ND |
|||||||||||||||||||||||||||||||||
| ATCC 19977 | M9501 | M9503 | M9507 | M9513 | M9522 | M9525 | M9526 | M9527 | M9528 | M9529 | M9530 | M9531 | M9502 | M9504 | M9505 | M9509 | M9510 | M9514 | M9515 | M9517 | M9521 | M9508 | M9518 | M9519 | M9523 | M9524 | M9533 | M9534 | M9551 | M9563 | M9565 | ||||
| OMC | 0.375 | 0.25 | 0.125 | 0.5 | 0.25 | 0.25 | 0.375 | 0.25 | 0.25 | 0.5 | 1 | 0.25 | 0.25 | 0.375 | 0.25 | 0.188 | 0.06 | 0.5 | 0.375 | 1 | 0.188 | 0.25 | 0.125 | 0.125 | 0.125 | 0.06 | 0.75 | 0.25 | 0.25 | 0.5 | 0.25 | 0.188 | 0.06 to 1 | 0.25 | 0.5 |
| TGC | 0.125 | 0.25 | 0.06 | 0.25 | 0.093 | 0.188 | 0.188 | 0.125 | 0.25 | 0.125 | 1 | 0.125 | 0.25 | 0.375 | 0.093 | 0.093 | ≤0.06 | 0.25 | 0.188 | 0.5 | 0.188 | 0.093 | 0.188 | 0.125 | 0.125 | ≤0.06 | 0.375 | 0.125 | 0.125 | 0.25 | 0.25 | 0.093 | 0.06 to 1 | 0.125 | 0.375 |
| AMK | 16 | 16 | 16 | >256 | 8 | 16 | >256 | >256 | >256 | >256 | >256 | 16 | 16 | 16 | 16 | 12 | 8 | 8 | 12 | 8 | 16 | 16 | 8 | 8 | 8 | 16 | 12 | 16 | 16 | 16 | 16 | 12 | 8 to >256 | 16 | >256 |
| CLR | 1 | ≤0.06 | 0.25 | 4 | 0.75 | 0.5 | 8 | 2 | 4 | 4 | 1 | 3 | 4 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | 0.125 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | 0.375 | 0.125 | 0.25 | ≤0.06 | 0.125 | 0.5 | ≤0.06 | ≤0.06 | 2 | ≤0.06 | 0.06 to 8 | 0.125 | 4 |
| AZM | 16 | 0.5 | 16 | 32 | 24 | 8 | 64 | 64 | 48 | 64 | 32 | 64 | 64 | 1 | 0.5 | 0.375 | 0.25 | 1 | 0.75 | 1 | 1.5 | 0.5 | 8 | 4 | 8 | 0.25 | 4 | 16 | 1 | 1 | 16 | 1 | 0.25 to 64 | 4 | 64 |
| IMI | 24 | 16 | 24 | 24 | 24 | 24 | 24 | 32 | 24 | 24 | 256 | 48 | 24 | 16 | 24 | 16 | 24 | 64 | 16 | 32 | 16 | 24 | 16 | 48 | 24 | 64 | 24 | 24 | 24 | 32 | 24 | 24 | 16 to 256 | 24 | 48 |
| DOR | 16 | 24 | 16 | 24 | 24 | 24 | 24 | 16 | 32 | 32 | 32 | 32 | 32 | 32 | 32 | 16 | 16 | 64 | 48 | 64 | 32 | 16 | 32 | 64 | 32 | 64 | 24 | 32 | 32 | 32 | 64 | 32 | 16 to 64 | 32 | 64 |
| FOX | 16 | 32 | 16 | 32 | 16 | 16 | 24 | 16 | 32 | 32 | 32 | 32 | 32 | 32 | 32 | 16 | 16 | 32 | 16 | 48 | 16 | 16 | 32 | 32 | 32 | 32 | 32 | 32 | 32 | 32 | 32 | 32 | 16 to 48 | 32 | 32 |
| CDR | 64 | 64 | 32 | 96 | 64 | 32 | 64 | 32 | 96 | 128 | 64 | 64 | 64 | 32 | 48 | 16 | 8 | 64 | 16 | 64 | 32 | 16 | 192 | 256 | 192 | 128 | 48 | 128 | 128 | 64 | 128 | 64 | 8 to 256 | 64 | 128 |
| CAZ | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 |
| AMX | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 |
| VAN | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | 128 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 |
| TEC | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 |
| LZD | 32 | 32 | 32 | 64 | 16 | 32 | 32 | 16 | 48 | 32 | 32 | 64 | 64 | 64 | 16 | 16 | 8 | 16 | 64 | 32 | 24 | 16 | 16 | 8 | 12 | 3 | 32 | 16 | 32 | 64 | 64 | 64 | 3 to 64 | 32 | 64 |
| CFZ | 0.25 | 0.25 | 0.188 | 0.188 | 0.375 | 0.375 | 0.25 | 0.125 | 0.25 | 0.25 | 0.188 | 0.375 | 0.188 | 0.25 | 0.25 | 0.25 | 0.093 | 1 | 0.25 | 0.188 | 0.25 | 0.25 | 0.093 | 0.093 | 0.188 | 0.125 | 0.375 | 0.25 | 0.25 | 0.188 | 0.25 | 0.125 | 0.09 to 1 | 0.25 | 0.375 |
| MOX | 16 | 16 | 16 | 32 | 16 | 32 | 16 | 16 | 64 | 32 | 64 | 8 | 16 | 32 | 8 | 8 | 8 | 32 | 32 | 64 | 8 | 8 | 6 | 8 | 8 | 2 | 16 | 8 | 8 | 16 | 16 | 6 | 2 to 64 | 16 | 32 |
| RFB | 8 | 8 | 8 | 8 | 8 | 16 | 8 | 8 | 8 | 8 | 16 | 16 | 16 | 16 | 8 | 4 | 4 | 4 | 8 | 4 | 8 | 8 | 8 | 4 | 8 | 1.5 | 16 | 12 | 8 | 16 | 32 | 6 | 1.5 to 32 | 8 | 16 |
| BDQ | <0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 |
a
MIC values are averages of two biological replicates. For agents with published CLSI breakpoints, resistant MIC values are denoted in bold and intermediate MIC values are denoted by underlines (49) (see Table S2 in the supplemental material). ND, M. abscessus isolates whose subspecies has not been determined.
b
OMC, omadacycline; TGC, tigecycline; AMK, amikacin; CLR, clarithromycin; AZM, azithromycin; IMI, imipenem; DOR, doripenem; FOX, cefoxitin; CDR, cefdinir; CAZ, ceftazidime; AMX, amoxicillin; VAN, vancomycin; TEC, teicoplanin; LZD, linezolid; CFZ, clofazimine; MOX, moxifloxacin; RFB, rifabutin; BDQ, bedaquiline.