TABLE 3.

Omadacycline PK parameters in BALB/c mice dosed via intraperitoneal injection

Omadacycline dose (mg/kg)	AUC0–24 (h · µg/mL)a		Cmax (µg/mL)b	t1/2 (h)c
	Total	Freea
2.5	2.26	1.49	0.73	4.21
7.5	6.51	4.30	1.32	9.53
15.0	17.18	11.36	4.16	6.31
30.0	28.13	18.59	5.87	3.33

^aFree AUC_0–24 was determined based on 33.9% plasma protein binding in BALB/c mice. AUC_0–24, area under the plasma concentration versus time curve (AUC) from time zero to 24 h after dosing, calculated using the linear trapezoidal linear interpolation method.

^bC_max, maximum observed plasma concentration.

^ct_1/2, plasma terminal elimination half-life, calculated as t_1/2 = ln(2)/λz, where λz is the terminal elimination rate constant calculated by linear regression of the terminal portion of the natural log of plasma concentration versus time curve.