Schematic model showing the function and phenotypes associated with RsbX. RsbX is required to prevent SigB activation at nonstressed conditions, thereby maximizing the fitness of the bacteria, motility, and biofilm formation. However, at conditions of stress, the SigB pathway is essential for bacterial survival. Exactly how RsbX interacts with the stressosome is not clear, and RsbX might play a role in biofilm formation independent of SigB.