FIG 3.
DectiSomes were more effective at reducing the burden of C. albicans in the kidneys compared with untargeted AmB-LLs. Neutropenic mice infected with C. albicans were treated with PBS (buffer control) or the indicated AmB loaded liposomes. Scatter bar plots compare the fungal burden in the kidneys following treatment. (A, B) DEC1-AmB-LLs or AmB-LLs delivering 0.2 mg AmB/kg or PBS. (C, D) DEC2-AmB-LLs or AmB-LLs delivering 0.2 mg AmB/kg or PBS. (E, F) The performance of targeted Anidulafungin loaded liposomes. (E) Comparison of free AFG to AFG-LLs delivering 1.8 mg/kg AFG. (F) Comparison of AFG-LLs to DEC2-AmB-LLs delivering 0.6 mg/kg AFG. CFU or the relative quantity (RQ) of C. albicans rDNA was determined in kidney homogenates from the same mice. Six to 12 mice were included in each treatment group. See treatment regimens displayed in Fig. S1A. Due to the nonparametric distribution of some CFU data P values (PMW) were calculated using the Mann-Whitney test in Prism.