FIG 4.

AmBisome, DEC2-Ambisome, and pegylated AmB-LLs compared in fungal burden and fungal binding assays. (A, B) The kidney fungal burden was examined after neutropenic mice infected with C. albicans were treated with liposomes. (A) Mice were treated with AmBisome or AmB-LLs delivering 2.0 mg AmB/kg or PBS. (B) Mice were treated with AmBisome and DEC2-AmBisome delivering 0.2 mg AmB/kg or PBS. See mouse treatment regimens displayed in Fig. S1A. (C, D, E) Fluorescent images showing the binding of Dectin targeted and untargeted rhodamine B tagged AmBisome to in vitro grown C. albicans. Fungal chitin was stained with CW. (F) Quantification of the liposome binding was estimated from multiple images such as those in C–E. Standard errors, fold differences in the average area of liposome staining, and P values are indicated.