. 2022 Jan 18;66(1):e01876-21. doi: 10.1128/AAC.01876-21

TABLE 2.

Potency of GSK’254 in the presence of serum in multiple-cycle assay^a

Virus	10% FBS			10% FBS + 40% HS + 27 mg/mL of HSA^b			Serum effect (±HS EC₅₀ ratio)
Virus	EC₅₀, nM	EC₉₀, nM	n	EC₅₀, nM	EC₉₀, nM	n	Serum effect (±HS EC₅₀ ratio)
Wild type	1.4	3.6	58	12.3	26.1	40	8.8
V370A	1.5	3.0	4	9.1	42.2	4	6.1
ΔV370	4.4	7.8	6	38.2	195	6	8.7

Assays used luciferase endpoint. FBS, fetal bovine serum; HS, human serum; HSA, human serum albumin.

Albumin concentration equivalent to 100% human serum.